'''Twiddle''' or '''Twiddling''' may refer to:
, an American rock band
, in Fast Fourier Transforms in mathematics
, action of the hands
, English idiom
character ( ~ ), sometimes referred to as "twiddle" or "squiggle"
*Mr Twiddle, zookeeper character in ''Wally Gator
'' animated TV series
*Victor Twiddle, a fictional character, assistant to Captain Paul Montford
in ''The Wolf Man''